Laboratory research · Aug 2024 to May 2025
Candida Crushers: Discovering Novel Antifungal Metabolites from Endophytic Fungi via a Bioassay-Guided Approach
Resistance is rising among Candida species, including Candida auris. We studied TAP14-269D-4, an endophytic Talaromyces species isolated from pine tree roots in Tapachula, Mexico, for its potent activity against C. albicans and C. auris. Using a bioassay-guided approach, we combined HRMS, NMR spectroscopy, and AI-assisted de-replication tools such as SMART NMR and DeepSAT to identify and characterize its secondary metabolites.
Presented at the Harvard Undergraduate Research Conference (HURC), FURC, and USF Castle
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